Development of a Solid Dispersion of Nystatin with Maltodextrin as a copyright Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

Development of a Solid Dispersion of Nystatin with Maltodextrin as a copyright Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

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The aim of this study was to improve the treatment of Candida albicans biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic copyright.Characterization studies by differential Generator Assembly scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity.Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques.The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins.Anti-biofilm assays showed a significant reduction (more than 80%) on Gift Card biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension.

The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.